(Cordyceps militaris) (fruiting body)

Cordyceps is a genus of ascomycete fungi that includes about 600 worldwide species. Diverse variants of cordyceps have had more than 1,500 years of use in Chinese medicine. According to the online publication Healthline, there are six major benefits of cordyceps, all back by science, including a boost in exercise performance, anti-aging properties, anti-tumor effects, blood sugar control, heart health, and inflammation fighting properties. Cordyceps mushrooms are also for their potential to improve cognitive function, including learning and memory, spatial perception, working memory and learning capacity. It is also known as the “athlete’s mushroom” providing improved physical performance, enhanced immune support, increased energy levels, increased oxygen utilization, and overall vitality.

(Hericium erinaceus) (fruiting body)

A staple of ancient Chinese medicine, Lion’s mane mushrooms are big, white pom-poms that resemble a lion’s mane. Although they’re generally thought of as a single type of mushroom, there are three different species. Hericium erinaceus is the most widely available. Lion’s mane mushrooms are rich in vitamins such as thiamine (B1) riboflavin (B2), and niacin (B3). They are also a good source of essential minerals such as manganese, zinc, and potassium. Research suggests that lion's mane may have several health benefits, including the slowing of cognitive decline, reducing anxiety, antioxidant and anti-inflammatory, nerve regeneration, and blood sugar control.

(Eurycoma Longifolia) (root)

Also known as longjack - Used for centuries in traditional Southeast Asian medicine, Tongkat Ali, or longjack, is an herbal remedy that comes from the roots of the green shrub tree Eurycoma longifolia, which is native to Southeast Asia. Tongkat Ali contains high levels of naturally occurring testosterone precursors, making it one of the most effective natural testosterone boosters available. The bioactive compounds eurycomanone inhibits the conversion of testosterone to estrogen, positively impacting male hormone levels. Tongkat Ali also contains flavonoids, alkaloids, and other compounds that act as antioxidants, fighting cellular damage caused by free radicals, and may have dozens of other health benefits for the body.

(Cissus quadrangularis) (aerial parts)

Cissus is a perennial plant of the grape family, commonly known as veldt grape, that grows in tropical Asia, the Arabian Peninsula and much of Africa. Traditionally, its plant parts are dried and made into powder to use as medicine. Cissus is commonly used as a precursor to boost serotonin levels. When serotonin is at normal levels, you feel more focused, emotionally stable, happier and calmer while low levels of serotonin are associated with depression. Many medications used to treat anxiety, depression and mood disorders often target ways to increase the level of serotonin in your brain. Healthy serotonin levels can improve mood, regulate stress and anxiety, improve learning and memory, regulate the appetite, and regulate circadian rhythms for quality sleep. Cissus also has antioxidant, pain-relieving, and anti-inflammatory effects, reducing inflammation in as little as 30 minutes after ingestion.

(Fadogia agrestis) (stem)

Fadogia is a shrub native to Nigeria and surrounding areas. The stem has been used for centuries in traditional African medicines to elevate energy levels, boost stamina, and to help improve hormone metabolism, which can play a crucial role in muscle development, maintaining muscle mass, and increasing muscle strength. Although clinical research is more limited than Tongkat Ali, the phytochemical constituents of Fadogia are thought to have similar effects on testosterone levels, muscle building, and athletic performance. Fadogia is known as “Black aphrodisiac” due to its purported ability to boost libido and sexual performance.

Everyone knows that Creatine increases muscle mass, improves athletic performance, reduces dehydration and cramping, and speeds recovery times after a workout, but few are aware of the benefits to brain health. Creatine supplementation may offer numerous cognitive benefits, including, improved memory and cognition, reduced mental fatigue, improved recovery from traumatic brain injury, reduced symptoms of depression and anxiety, improved cognitive processing, and improved processing speed. Creatine is stored in muscle and brain cells as phosphocreatine, which helps regenerate adenosine triphosphate (ATP), an energy-providing molecule. When demand for energy is high, muscle and brain cells use creatine to access more energy. Creatine is found in meat, fish, and some dairy products although typical creatine supplement doses are much higher than the amount of creatine most people get from their diet.

The organic compound citrulline is an α-amino acid. Its name is derived from citrullus, the Latin word for watermelon. Citrulline supplementation increases the body’s arginine levels, the main substrate for the synthesis of nitric oxide, increasing nitric oxide production in the body. Given the role of nitric oxide in vasodilation, mitochondrial respiration, and glucose uptake, greater amounts of nitric oxide can increase blood flow, improve muscle function, reduce fatigue, and speed recovery after a workout or intense physical activity. According to some studies, L-citrulline can help increase oxygen uptake and muscle oxygenation. When your muscle tissues receive more oxygen and nutrients, they function better and recover more quickly. L-Citrulline helps the body use oxygen and blood flow more efficiently, which can improve cognitive function and brain performance. Nitric oxide is also involved in the formation of long-term memories.

(Asphaltum punjabianum)

Used in traditional Ayurvedic and Siddha medicine for centuries, shilajit is a sticky, naturally occurring, black resin found in cracks in the high mountain ranges of Asia. Shilajit is made up of organic plant material, humus, and other substances, including high concentrations of fulvic acid, vitamins, amino acids, essential fatty acids, and 84 different minerals. Fulvic acid is a powerful antioxidant that contributes to cognitive health by preventing an unhealthy buildup of tau protein, that can trigger brain cell damage. Other health benefits include improved memory, immunity support, anti-inflammatory properties, and reduced fatigue. Regular use of shilajit may contribute to longevity, a slower aging process, improved heart health, and overall better health.

(Bixa orellana) (seeds)

providing mixed tocotrienols (delta, gamma) - Annatto is a spice and natural food coloring that comes from the seeds of the achiote tree, also known as Bixa orellana. It is native to tropical regions of Central and South America but is grown in many countries around the world. Annatto is rich in antioxidants like tocotrienols, tocopherols, carotenoids, terpenes, and flavonoids. It is an abundant source of tocotrienols, a group of compounds that are part of the vitamin E family. Tocotrienols provide neuroprotection, in other words, they protect brain cells. Studies have indicated that tocotrienols may be 40-60 times more potent as antioxidants than tocopherols, the form of vitamin E commonly available in supplements.

(Camellia sinensis) (leaf)

Grown throughout East Asia, green tea is made from Camellia sinensis leaves and buds that have not undergone the same withering and oxidation process used to make oolong teas and black teas. It's been a popular drink as well as a traditional medicine in China and Japan for thousands of years. Green tea has too many therapeutic benefits to list them all, including weight loss, kidney function, heart health, gut health, skin health, blood sugar control, blood pressure control, antioxidants, anti-inflammatory, and more. Green tea may help with focus and attention and may protect the brain. It also contains l-theanine, which relaxes the brain without causing drowsiness.

(Piper nigrum) (fruit)

Black pepper contains piperine, a plant compound that provides many health benefits. When black pepper is provided as a 95% standardized extract, the piperine is isolated and purified, making up 95% of the total amount of black pepper material used in the product. Piperine is commonly used to help maximize the absorption of the other nutrients in the formulation, but it possesses health benefits of its own, including better digestion, reduced cholesterol, and improved cognitive brain function. It also has antioxidant, anti-inflammatory, and antimicrobial properties.

(as boron glycinate)

Boron is a trace element that may play a role in human brain function and cognitive performance. Studies have shown that low levels of boron in the diet can lead to poorer performance on tasks that involve motor speed and dexterity, attention, Short-term and long-term memory, hand-eye coordination and perception. Boron deprivation can also cause decreased brain electrical activity, with a shift towards more low-frequency activity and less high-frequency activity. This shift is similar to what is seen in response to malnutrition and heavy-metal toxicity. Low-frequency activity is associated with reduced mental alertness and impaired memory performance, Boron is also important for bone health, healing, and healthy hormone levels.

(as cholecalciferol)

100% USRDA - Without Vitamin D, bones can become weak and fragile. Although Vitamin D is critical for bone health, there are numerous equally important benefits, including support for a healthy brain, heart, teeth and lungs. It plays a key role in brain cell function and development, and a deficiency can have adverse effects on the brain. Vitamin D also helps regulate insulin levels, enhance mood, and elevate energy levels. According to Mayo Clinic, Vitamin D’s anti-inflammatory, antioxidant and neuroprotective properties support immune health, muscle function and brain cell activity. Cholecalciferol, also known as vitamin D3 is a type of vitamin D that is produced by the skin when exposed to UVB light, is found in certain foods, and can be taken as a dietary supplement.

(as pyridoxine HCl)

400% USRDA - According to the Mayo Clinic, Vitamin B-6 (pyridoxine) is “important for normal brain development and for keeping the nervous system and immune system healthy.” B6 produces neurotransmitters, like serotonin, that help regulate mood, aid sleep, and reduce anxiety. The body uses small amounts of B6 for hundreds of chemical reactions that help to maintain whole body health. Vitamin B6 is water soluble so the body disposes of excess B6 through urine and the body does not naturally produce B6 so we must consistently replenish it through the food we eat or with supplementation. A deficiency of vitamin B6 has been associated with reduced brain function.

(as methylcobalamin)

800% USRDA - Among the hundreds of different functions within the body, Vitamin B12 is essential for the normal functioning of the brain and nervous system. It helps produce serotonin and dopamine, which are neurotransmitters that can help improve mood and reduce anxiety and depression. It helps to improve focus and memory. It helps form red blood cells so the body can absorb iron, increase hemoglobin levels, and overcome fatigue, weakness, and shortness of breath. It helps create and regulate DNA, the genetic material in cells. B12 helps convert carbohydrates into glucose, which the body uses for energy and alertness. A deficiency of vitamin B12 has been associated with fatigue, disrupted sleep cycles, and reduced brain function.

(as magnesium L-threonate)

Magnesium L-threonate (MgT) is a magnesium salt of L-threonic acid that is known for its ability to cross the blood-brain barrier making it the magnesium of choice to support brain health, memory, cognitive vitality, executive function, stress relief and sleep quality. MgT increases magnesium levels in the brain to improve neural plasticity and synaptic density leading to better neural communication and cognition. It may also help to reduce memory impairment and inflammation caused by alcohol abuse. Study indicate that magnesium L-threonate is the best form of magnesium for brain support.

(as amino acid chelate)

100% USRDA - Zinc is an essential trace mineral found in cells throughout the body and is the second most common mineral in the body after iron. A varied diet usually provides enough zinc, but supplementation is common. Zinc has many benefits for the body, including growth and development, blood sugar control, healing, metabolism, cardiovascular health, and immune support. Zinc is essential for brain activity and is highly concentrated in the brain. It is believed to play a key role in regulating how neurons communicate, which is important for learning and memory. Zinc is also thought to be a key factor in regulating adult brain stem cell proliferation and neurogenesis. zinc deficiency can lead to memory problems and foggy thinking.